2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

PDF 2.47 MB

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-152598
    N1-Methylxylo-guanosine
    N1-Methylxylo-guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N1-Methylxylo-guanosine
  • HY-154430
    2’-Deoxy-N2-cyclopentyl guanosine
    2’-Deoxy-N2-cyclopentyl guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-N2-cyclopentyl guanosine
  • HY-180605
    9,10,18-Trihydroxystearic acid
    9,10,18-Trihydroxystearic acid is a C18 family of hydroxy acid.
    9,10,18-Trihydroxystearic acid
  • HY-180709
    L-Metanephrine
    L-Metanephrine is a nucleoside metabolite.
    L-Metanephrine
  • HY-154207
    2’-O-Acetyl-N4-benzoyl-5’-O-DMT arabinocytidine 3’-O-phosphoramidite
    2’-O-Acetyl-N4-benzoyl-5’-O-DMT arabinocytidine 3’-O-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-O-Acetyl-N4-benzoyl-5’-O-DMT arabinocytidine 3’-O-phosphoramidite
  • HY-154718
    2-Amino-6-chloropurine-3’,5’-di-O-acetyl-2’-deoxyriboside
    2-Amino-6-chloropurine-3’,5’-di-O-acetyl-2’-deoxyriboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Amino-6-chloropurine-3’,5’-di-O-acetyl-2’-deoxyriboside
  • HY-180704
    3-Methoxy-4-hydroxyphenylglycolaldehyde
    3-Methoxy-4-hydroxyphenylglycolaldehyde is a nucleoside metabolite.
    3-Methoxy-4-hydroxyphenylglycolaldehyde
  • HY-180732
    1-Pyrroline-4-hydroxy-2-carboxylate
    1-Pyrroline-4-hydroxy-2-carboxylate is a nucleoside metabolite.
    1-Pyrroline-4-hydroxy-2-carboxylate
  • HY-152868
    3’-O-(2-Azidoethyl)adenosine
    3’-O-(2-Azidoethyl)adenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-O-(2-Azidoethyl)adenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3’-O-(2-Azidoethyl)adenosine
  • HY-154461
    5-Azidomethyl-2’,3’,5’-tri-O-benzoyl uridine
    5-Azidomethyl-2’,3’,5’-tri-O-benzoyl uridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis. 5-Azidomethyl-2’,3’,5’-tri-O-benzoyl uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    5-Azidomethyl-2’,3’,5’-tri-O-benzoyl uridine
  • HY-152817
    2′-β-C-Methyl-beta-D-6-methylpurine riboside
    2′-β-C-Methyl-beta-D-6-methylpurine riboside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2′-β-C-Methyl-beta-D-6-methylpurine riboside
  • HY-152301
    3’-Deoxy-3’-fluoro-N6-methyladenosine
    3’-Deoxy-3’-fluoro-N6-methyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-Deoxy-3’-fluoro-N6-methyladenosine
  • HY-W564313
    2',3'-O-Isopropylidene-5-pyrrolidinomethyl-2-thiouridine
    2',3'-O-Isopropylidene-5-pyrrolidinomethyl-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2',3'-O-Isopropylidene-5-pyrrolidinomethyl-2-thiouridine
  • HY-152636
    2-Cyanomethylthioadenosine
    2-Cyanomethylthioadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2-Cyanomethylthioadenosine
  • HY-154000
    3,5’-Bis(O-t-butyldimethylsilyl)-2’-O-methyl-5-methyl cytidine
    3,5’-Bis(O-t-butyldimethylsilyl)-2’-O-methyl-5-methyl cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    3,5’-Bis(O-t-butyldimethylsilyl)-2’-O-methyl-5-methyl cytidine
  • HY-154131
    3-Deaza-xylouridine
    3-Deaza-xylouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3-Deaza-xylouridine
  • HY-152477
    3’-β-C-Ethynyladenosine
    3’-β-C-Ethynyladenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277). 3’-β-C-Ethynyladenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    3’-β-C-Ethynyladenosine
  • HY-141897
    3-Deoxy-D-arabino-heptulosonate 7-phosphate
    3-Deoxy-D-arabino-heptulosonate 7-phosphate is produced by the condensation of D-erythrose 4-phosphate with phosphoenolpyruvate (PEP), catalyzed by 3-deoxy-d-arabino-heptulosonate 7-phosphate (DAH 7-P) synthase (phe).
    3-Deoxy-D-arabino-heptulosonate 7-phosphate
  • HY-180760
    Ciliatocholate
    Ciliatocholate (Ciliatocholic acid) is a nucleoside metabolite.
    Ciliatocholate
  • HY-152438
    6-Amino-3-ethynyl-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
    6-Amino-3-ethynyl-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 6-Amino-3-ethynyl-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    6-Amino-3-ethynyl-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine